In this paper, the finite element method is used to analyse the crack behaviour in the orthopedic cement of the total hip replacement by computing the stress intensity factors (SIFs) arround the crack tip. In this work, three cases are studied: crack emanating from a cavity, interaction effect of the crack emanating from a cavity with another cavity and the interaction effect of two cracks emanatingfrom two cavities. The stress intensity factors under mixed mode problems at the crack tip are computed for three zones of prosthesis: proximal, median and distal. The obtained results show that the crack initiated from a micro-cavity in the distal zone of cement can be propagated at the same time by opening and shearing of its lips. It is contrary to that initiated in the proximal zone which cannot be propagated. The mechanical behaviour of cracks in the medial zone depends of the crack initiation position.