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ARTICLE
Tribological effects of hyaluronic acid concentration on articular cartilage: pin-on-plate friction tests in porcine and osteoarthritic human tissue
1
Faculty of Mechanical Engineering, Bydgoszcz University of Science and Technology, Bydgoszcz, Poland
2
Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland
3
Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Toruń, Poland
4
Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland
Submission date: 2025-07-05
Final revision date: 2025-08-22
Acceptance date: 2025-09-15
Online publication date: 2025-10-13
Corresponding author
Adam J. Mazurkiewicz
Mechanical Engineering Faculty, University of Science and Technology, Kaliskiego 7, 85-796, Bydgoszcz, Poland
Mechanical Engineering Faculty, University of Science and Technology, Kaliskiego 7, 85-796, Bydgoszcz, Poland
KEYWORDS
TOPICS
ABSTRACT
Hyaluronic acid (HA) is the main biopolymer used in intra-articular injections for osteoarthritis (OA). HA is usually applied at 1–3 mg/mL, though the optimal level remains unclear. The purpose of this study was to determine the effect of HA concentration on the friction in osteoarthrosis.
Samples from the osteoarthritic head of a human femur and porcine controls were tested in a pin-on-plate setup. The results showed a statistically significant effect of HA concentration on the friction in a group of porcine cartilage. In a group of osteoarthritic cartilage, such a relationship did not occur. This comparison highlights that degeneration limits HA’s effect.
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