The paper presents the comparison of experimental and calculated fatigue lives for EN AW-6082 T6 aluminium alloy. Hour-glass shaped specimens have been subjected to constant and variable amplitude uniaxial and multiaxial loadings, i.e. plane bending, torsion and their proportional combinations with zero mean values. Three multiaxial fatigue criteria based on the critical plane approach have been verified being the linear combination of shear and normal stresses on the critical plane. For the variable-amplitude loading, the rainflow cycle counting method and Palmgren-Miner hypothesis have been applied. The best fatigue criteria are pointed in the final conclusions.